In the world of One Piece, powerful characters with extraordinary Devil Fruits are a common sight. The main protagonist, Monkey D. Luffy, is no exception as he possesses the Hito Hito no Mi, Model: Nika - a Mythical Zoan-type Devil Fruit. However, its true name has been erased to conceal its immense power. With the help of this Devil Fruit, Luffy's physical abilities are significantly enhanced, enabling him to endure countless attacks. Undeniably, the Hito Hito no Mi, Model: Nika is one of the most dominant Devil Fruits in One Piece, but there are still ways to counter its effects.
6 Haki
There are two types of Haki that can be learned through training: Busoshoku Haki and Kenbunshoku Haki. Busoshoku Haki can be used for both defense and attack against Devil Fruit users, allowing those who master it to break through even the most formidable defenses. However, the rarest type of Haki is Haoshoku Haki, which greatly increases damage output but is incredibly difficult to learn. Only a select few characters are capable of infusing this type of Haki into their attacks, such as Kaido who demonstrated its effectiveness against the Hito Hito no Mi, Model: Nika.
5 Yami Yami no Mi
Blackbeard's acquisition of the Yami Yami no Mi, a powerful Devil Fruit, led him to become one of the Emperors. With the ability to create and control darkness, anything consumed by the darkness is crushed under the amplified force of gravity. Additionally, the Yami Yami no Mi can nullify the power of other Devil Fruits, as demonstrated when Blackbeard negated the effects of Luffy's Devil Fruit during their confrontation in Impel Down.
4 Biological Weapons
There are a plethora of biological weapons in One Piece that have the capability to take down even the strongest of characters. Jack utilized Caesar's poison gas in Zou, which had devastating effects on the Mokomo Dukedom and made the job of the Beasts Pirates a lot easier. In the Wano Country arc, Queen introduced two of his most lethal creations: the Mummy virus and the Ice Oni virus.
While the Mummy virus is non-lethal, it can cause severe fever and blood loss. It is also highly contagious and can spread rapidly. On the other hand, the Ice Oni virus is much more dangerous as it enhances an individual's physical abilities while impairing their senses. Those infected with the virus also take on the appearance of an Oni and succumb to its effects within an hour. Against these biological weapons, the Hito Hito no Mi, Model: Nika is rendered useless.
3 Seraphim
Dr. Vegapunk's project to create the Seraphim was already underway before the Straw Hats had encountered Kuma, but it wasn't until after the time skip that it was finally completed. The arduous process required an immense amount of resources and dedication, but the end result proved to be impressive. The Seraphim are equipped with Devil Fruits that complement their fighting style, and their Lunarian traits grant them unparalleled physical abilities. Their power is evident in S-Hawk's ability to slice off a chunk of a mountain with a single slash. In addition, the Seraphim have demonstrated their ability to withstand significant amounts of damage. Luffy's Devil Fruit may prove ineffective against these formidable opponents.
2 Ope Ope no Mi
With the Ope Ope no Mi Devil Fruit, Trafalgar Law possesses a unique and highly sought-after ability that falls under the Paramecia-type category. Using this power, he can create ROOMs and manipulate everything within them. What's more, he can even override the effects of other Devil Fruits, a rare and impressive feat, such as when he emulates Corazon's Nagi Nagi no Mi by creating a soundproof room. Additionally, this Devil Fruit has the potential to grant immortality to another person, though at a steep cost to the user. If the Ope Ope no Mi were to fall into the hands of a skilled Haki user, they could easily counter the powers of the Hito Hito no Mi, Model: Nika.
1 Characters With High Stamina
However, the high stamina consumption of Luffy's Gear Fifth remains a significant drawback. Its usage drains his energy rapidly and requires careful management. Once Luffy reaches exhaustion, it takes considerable time for him to recover and revert to his normal state. Despite the immense destructive power it provides, Luffy's ability to participate in prolonged battles is limited. Other characters, such as Kaido, possess extraordinary stamina that surpasses Luffy's. Nevertheless, with training and mastery of his Devil Fruit, Luffy could potentially overcome this weakness and emerge victorious in future battles.