The autopsy report released by the Los Angeles Medical Examiners Office on Friday reveals that Friends star Matthew Perry passed away due to the "acute effects of ketamine" and subsequent drowning. Perry's blood tested positive for ketamine, a substance used to treat depression and anxiety.
The report states that the high levels of ketamine found in his postmortem blood specimens would have caused lethal effects from cardiovascular overstimulation and respiratory depression. Perry was found floating face down in the pool of his Malibu home in October, and authorities have ruled out foul play.
According to the autopsy report, Perry was receiving ketamine infusion therapy for depression and anxiety. The report also clarifies that ketamine is used as an anesthetic for medical and surgical purposes, but is also used recreationally due to its dissociative effects, causing a disconnection between the mind and body. Additionally, it can produce short-term hallucinatory and psychedelic effects.
Perry's most recent treatment occurred a week and a half before his death, according to the autopsy, far exceeding the amount of time it would typically remain in his system after treatment. This story is ongoing and will be revised as more information becomes available.